报告题目：Recent Progress on Activatable Photosensitizers and Fluorescent Probes

报 告 人： Prof. Juyoung Yoon

Ewha Womans University, Korea

报告地点：无机/超分子楼 二楼圆形报告厅

报告时间：2019年12月04日（星期三）下午15:00


报告人简介：

RESEARCH INTERESTS

Fluorescent Probes; Activatable Photosensitizers; Theranostics

PUBLICATIONS

350 SCI research papers. (h-index: 98)

CURRENT SCIENTIFIC ACTIVITIES

Editorial Advisory Board; Chemical Society Reviews (RSC), Scientific Reports (Nature Publishing Group), ACS Applied Materials & Interfaces (ACS), ACS Sensors (ACS), Chem (Cell Press), Sensors and Actuators B (Elsevier), Materials Chemistry Frontiers (RSC), Chinese Chemical Letters (Elsevier), ACS Omega (ACS), ACS Applied Bio Materials (ACS)

2015 – Present Executive Editor; Dyes & Pigments (Elsevier)

2017 – Present Associate Editor; Coordination Chemistry Reviews (Elsevier)

2014 – Present Fellow of Royal Society of Chemistry (RSC)

2014 – Present a member of Korean Academy of Science and Technology

listed as highly cited researcher in chemistry of 2014-2019

AWARDS

2019.10: 2nd Korea Toray Science Award (Korea Toray Science Foundation)

2016. 5.; Ewha Academic Award

2016. 4.: Korean Chemical Society Award

2014.3 - present: “Distinguished Professorship” by Ewha Womans University

2012. 11: “Knowledge Creation Grand Prize” by Ministry of Science and Technology of Korea

2012.9-2014.2: “Future Distinguished Professorship” by Ewha Womans University

2011. 10: “Monthly Best Scientist Award” by Ministry of Science and Technology of Korea

2008: “Shim Sang Chul Award” from Organic Division of Korean Chemical Society


报告简介：

Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine.1 Here, we develop a “one-for-all” nanomaterial (NanoPcTBs) that self-assembles from flexible and versatile phthalocyanine building blocks.2 Fluorescence and reactive oxygen species (ROS) generation could be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy (PDT). We also reported a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which have the capability of undergoing nucleic acid-responsive disassembly.3 On the other hand, the in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, was recently confirmed using an inducible transgenic mouse system.4 In addition, we demonstrated that a new, nanostructured phthalocyanine assembly, NanoPcA, inherently possesses the ability to promote highly efficient ROS generation via the type I mechanism.5 Recently, we also demonstrated the first comprehensive molecular design of heavy-atom-free triplet PSs based on thiocarbonyl naphthalimides with excellent potential in PDT.6 Finally, recent progress from our group on the fluorescent probes based on N-heterocyclic carbene (NHC) boranes for HOCl7 will be also presented.


References

1 Li, X.; Lee, S.; Yoon, J. Chem. Soc. Rev. 2018, 47, 1174-1188.

2 Li, X.; Kim, C-y.; Lee, S.; Lee, D.; Chung, H.-M.; Kim, G.; Heo, S.-H.; Kim, C.; Hong, K.-S.; Yoon, J. J. Am. Chem. Soc. 2017, 139, 10880-10886.

3 Li, X.; Yu, S.; Lee, D.; Kim, G.; Lee, B.; Cho, Y.; Zheng, B.-Y.; Ke, M.-R.; Huang, J.-D.; Nam, K. T.; Chen, X.; Yoon, J. ACS Nano 2018, 12, 681-688.

4 Li, X.; Yu, S.; Lee, Y.; Guo, T.; Kwon, N.; Lee, D.; Yeom, S. C.; Cho, Y.; Kim, G.; Huang, J.-D.; Choi, S.; Nam, K. T.; Yoon, J. J. Am. Chem. Soc. 2019, 141, 1366-1372. (Cover)

5 Li, X.; Lee, D.; Huang, J.-D.; Yoon, J. Angew. Chem. Int. Ed. 2018, 57, 9885-9890. (Hot Paper)

6 Nguyen, V.-N.; Qi, S.; Kim, S.; Kwon, N.; Kim, G.; Yim, Y.; Park, S.; Yoon, J. J. Am. Chem. Soc. 2019, 141, 16243-16248.

7 Pak, Y. L.; Park, S. J.; Wu, D.; Cheon, BH.; Kim, H. M.; Bouffard, J.; Yoon, J. Angew. Chem. Int. Ed. 2018, 57, 1567-1571.